Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity
نویسندگان
چکیده
منابع مشابه
Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity.
BACKGROUND Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat ...
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In the title compound, C17H17NO2, the carbazole skeleton includes an eth-oxy-carbonyl group at the 3-position. The indole three-ring system is almost planar [maximum deviation = 0.065 (2) Å], and the ethyl ester group is inclined to its mean plane by 15.48 (2)°. In the crystal, there are π-π stacking inter-actions between parallel benzene rings and between parallel benzene and pyrrole rings of ...
متن کاملtert-Butyl 6-bromo-1,4-dimethyl-9H-carbazole-9-carboxylate
The title compound, C(19)H(20)BrNO(2), consists of a carbazole skeleton with methyl groups at positions 1 and 4, a protecting group located at the N atom and a Br atom at position 6. The pyrrole ring is oriented at dihedral angles of 1.27 (7) and 4.86 (7)° with respect to the adjacent benzene rings. The dihedral angle between the benzene rings is 5.11 (7). The crystal structure is determined ma...
متن کاملCrystal structure of dimethyl 9H-carbazole-2,7-dicarboxylate
In the title compound, C16H13NO4, the carbazole ring system is almost planar with non-H atoms possessing a mean deviation from planarity of 0.037 Å. The two ester groups are orientated trans to one another and tilted slightly from the mean plane of the carbazole ring system, making dihedral angles of 8.12 (6) and 8.21 (5)°. In the crystal, mol-ecules are linked by pairs of N-H⋯O hydrogen bonds ...
متن کامل3,6-Diiodo-9H-carbazole
In the title compound, C(12)H(7)I(2)N, the tricyclic aromatic ring system is essentially planar, with an r.m.s. deviation of 0.0272 Å. The two I atoms are marginally out of plane, with the C-I bonds angled at 3.9 (2) and 1.1 (2)° with respect to the planes of their respective benzene rings, above and below the plane of the carbazole ring system. No classical hydrogen bonds are observed in the c...
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ژورنال
عنوان ژورنال: Molecules
سال: 2018
ISSN: 1420-3049
DOI: 10.3390/molecules23020286